DSIP

DSIP Unit Size :2 mg/vial
DSIP Unit Quantity :1 Vial
DSIP Purity: 99.0%min
Delta sleep-inducing peptide(DSIP)
Sequence:r-l-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Specification: 2mg/vial;
CAS#: 62568-57-4
Formula: C35H48N10O15
Molecular Weight: 848.81
Place of Origin: China
Standard: USP
Certification: SGS
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.


Sleep Inducing Peptide DSIP effects :
DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia. DSIP also significantly altered bilateral symmetry of EEG.

DSIP probably reduced parasympathetic tone and decreased (lightened) the depth of anaesthesia measured using BIS.



Dsip(Delta sleep-inducing peptide) METHODS:
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) at 25, 50 or 100 nmol kg(-1). The first administration of DSIP was while awake and the second after induction of anaesthesia with propofol and maintenance with isoflurane. BIS and EEG parameters were measured continuously using a bilateral electrode montage.